Anthracnose fruit rot (AFR) is the most significant disease that directly affects the fruit of blueberries in Florida. In years past, AFR, also known as ripe rot, has been of minor concern for Florida growers; however, within the last three to five years, reports of substantial losses are on the rise. In this article, we will try to understand the disease cycle, factors that can promote disease, and management tools to reduce disease risk in your field. AFR is a real heartbreaker that can not only reduce the amount of harvestable fruit just as the year’s investment starts to pay out but then come back with the sucker punch of reducing the quality and quantity of the harvested berries due to fruit spoilage, lower pack-outs, and shorter shelf life.